Liver disease

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Liver disease

Liver Cirrhosis

Liver cirrhosis is a chronic liver disease in which liver cells are damaged, and excessive fibrotic tissue forms to replace them, leading to abnormal changes in liver structure and reduced function. The primary causes include viral infections such as hepatitis B or hepatitis C, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune diseases, toxic substances, medications, and genetic disorders.

  • Causes of Liver Cirrhosis Liver cirrhosis is a chronic liver disease in which liver cells are damaged, and excessive fibrotic tissue forms to replace them, leading to abnormal changes in liver structure and reduced function. The primary causes include viral infections such as hepatitis B or hepatitis C, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune diseases, toxic substances, medications, and genetic disorders.
  • Mechanisms of Stem Cell Therapy for Liver Cirrhosis Stem cells can replace damaged liver cells and promote liver tissue regeneration through their ability to differentiate into various cell types. Additionally, their anti-inflammatory and immunomodulatory properties can prevent and eliminate the causes of liver cirrhosis and contribute to its treatment.
  • bBHC's Research on Liver Cirrhosis Treatment KHCs are pluripotent stem cells capable of differentiating into hepatocytes.
    Differentiation of KHCs into Hepatocytes
    KHCs can differentiate into hepatocytes in the body, replacing damaged liver cells and regenerating damaged liver tissue. When KHCs were transplanted into a liver fibrosis model mouse, they reduced collagen, a key protein involved in fibrosis.
    Reduction of Collagen in Fibrotic Liver Tissue Following KHC Transplantation (Fluorescent Immunohistochemistry)
    The transplantation of KHCs into the tail vein reduced collagen levels in fibrotic liver tissue by 35.43% (single transplantation) and 41.64% (five transplantations).
    Reduction of Collagen in Fibrotic Liver Tissue Following KHC Transplantation (IHC)
    Moreover, KHC transplantation reduced the collagen deposition area in fibrotic liver tissue by 53.31% (single transplantation) and 56.78% (five transplantations). As a result, the Batts-Ludwig scoring system for liver fibrosis grades showed a reduction from grade 2 before KHC transplantation to grade 1 in approximately 70% of cases after transplantation. Until now, liver cirrhosis treatment has only been possible by inhibiting the progression of fibrosis. However, these results indicate that removing fibrosis and regenerating damaged liver tissue is now possible, enabling a fundamental treatment for liver cirrhosis.