STRI

Cancer

The mechanisms by which stem cells treat cancer have been studied extensively
with several key pathways identified:

Generation of Immune Cells Hematopoietic stem cells can differentiate into immune cells such as T cells, B cells, and NK cells, which attack cancer cells and enhance the immune system's ability to fight cancer.
Immune Regulation Certain stem cells can stimulate or regulate the immune system, improving immune responses and intensifying the attack on cancer cells. They can also enhance tissue inflammatory conditions, alter the environment, and support cancer cell growth.
Cell Replacement Stem cells can regenerate damaged tissues or cells. By differentiating into normal cells, they can restore tissues compromised by cancer.
Modification of the Tumor Microenvironment Stem cells can influence the microenvironment where cancer cells thrive. Growth factors or cytokines secreted by stem cells can inhibit cancer cell growth or promote the regeneration of normal tissues.
Induction of Cancer Cell Death Substances secreted by stem cells can induce apoptosis (programmed cell death) in cancer cells, reducing their survival.

These mechanisms highlight why stem cell-based therapies are increasingly considered a promising cancer treatment approach.

KHCs can attack cancer through various mechanisms.

Differentiation into Hematopoietic Stem Cells KHCs can differentiate into hematopoietic stem cells.

Hematopoietic Stem Cells Derived from KHCs

Hematopoietic stem cells derived from KHCs can further differentiate into T cells, enhancing the attack on cancer cells.

T cell derived from KHC derived Hematopoietic stem cell

It indicates that transplanted KHCs can differentiate into hematopoietic stem cells and subsequently into T cells, B cells, and NK cells, thereby intensifying the attack on cancer cells.
Increased Expression of Tumor Suppressor Genes KHCs exhibit increased expression of tumor suppressor genes such as PTEN, Egr1, Egr2, Lrig1, CD81, and CD82.
Promotion of Cancer Cell Death The elevated expression of tumor suppressor genes in KHCs induces cancer cell death in vitro.

Induction of Breast, Colon, and Cervical Cancer Cell Death by KHCs
Inhibition of Cancer Cell Metastasis KHCs induce cancer cell death and inhibit cancer cell metastasis in vitro.

Anti-Metastatic Ability of KHCs
Replacement of Damaged Cells and Tissues KHCs, as pluripotent stem cells, migrate to damaged tissues in the body and promote regeneration. KHCs target cancer cells for destruction and regenerate damaged tissues, facilitating quicker recovery and return to daily life.